Fig. 3.

Atp7b^ΔHep mice do not show pathology up to 30 wk, have normal intestinal morphology, and do not upregulate TLR4. A: representative histology (hematoxylin and eosin staining) of liver sections from Atp7b^ΔHep, Atp7b^−/−, and Atp7b^Lox/Lox mice at different ages illustrates morphologic changes in Atp7b^−/− liver, whereas histomorphology for Atp7b^ΔHep is similar to that of Atp7b^Lox/Lox mice. B: histology of intestinal sections from 52-wk-old Atp7b^ΔHep mice and controls demonstrates the lack of pathologic changes in intestine. C: TLR4 mRNA expression in 20-wk liver of Atp7b^ΔHep, and Atp7b^Lox/Lox mice (n = 4–7). Data were analyzed using a two-tailed unpaired t-test.