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Effects of a single injection of amiloride (0.6 mg/kg) on renal electrolyte excretion and the expression of ENaC and NCC. Amiloride increased Na+ excretion and decreased K+ excretion over a 2-h period; plasma K+ increased significantly. Western blot analysis revealed significant increases in the cleaved form of α- and both total and cleaved γENaC, and decreased pT53NCC levels. Data represent means ± SE for 4 animals. *Statistical significance (P < 0.05).
