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Effects of a single injection of furosemide (6 mg/kg) + amiloride (0.6 mg/kg) or HCTZ (30 mg/kg) + amiloride (0.6 mg/kg) on renal electrolyte excretion and the expression of γENaC and pNCC. In both conditions Na+ excretion increased while K+ excretion decreased over a 2-h period; plasma K+ increased in both cases. With both treatments levels of cleaved γENaC increased, while those of pT53NCC decreased. Data represent means ± SE for 4 animals. *Statistical significance (P < 0.05).
