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Effects of spironolactone on urinary electrolyte excretion and ENaC and NCC expression. Rats were given a single injection of either aldosterone alone or aldosterone + spironolactone. Spironolactone increased Na+ excretion but had no significant effect on K+ excretion. Spironolactone decreased the level of both total and cleaved αENaC and of cleaved γENaC observed 5 h after administration of aldosterone. Data represent means ± SE for 4 animals. *Statistical significance (P < 0.05).
