Table 3.

UniProt annotations of proteins involved in transcriptional regulation

Gene Symbol	UniProt Functional Annotation
Jup	Common junctional plaque protein. Membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of Jup in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace β-catenin in E-cadherin/catenin adhesion complexes, which are proposed to couple cadherins to the actin cytoskeleton. [Translocates to nucleus in response to vasopressin (62). Jup can activate the Wnt signaling cascade directly without interaction of β-catenin, and has multiple functions as a transcriptional activator and a cell adhesion molecule like β-catenin (45).]
Tdrd3	Scaffolding protein that specifically recognizes and binds dimethyl arginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. May play a role in the assembly and/or disassembly of mRNA stress granules and in regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethyl arginine-containing proteins.
Lgr4	Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3, or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt, triggering the canonical Wnt signaling pathway to increase expression of target genes. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract, and eye. May also act as a receptor for norrin (NDP); such results, however require additional confirmation in vivo. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state.
Cdh1	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions and mobility and proliferation of epithelial cells. It is a ligand for integrin α-E/β-7.1 E-Cad/CTF2 promotes nonamyloidogenic degradation of Aβ precursors. Has a strong inhibitory effect on APP C99 and C83 production. [Cleaved Cdh1 translocates to nucleus to regulate transcription (15).]
Cenpj	Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome.
Taf1	Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel NH2- and COOH-terminal Ser/Thr kinase domains, which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on Thr55, which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity toward histones H3 and H4.

Square brackets indicate additional material culled from the literature.