Table 5.
Gene Symbol | UniProt Annotation |
---|---|
Plec | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. |
Cdh1 | See Table 3. |
Krt4 | Cytokeratin-4. |
Lrba | May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules. [Involved in endosomal traffic and may be involved in efficient delivery of cell surface proteins to the lysosome (11).]. |
Sptbn2 | Probably plays an important role in membrane skeleton; interacts with Epb41l1. [Spectrin is a cytoskeletal protein that lines the intracellular side of the plasma membrane in eukaryotic cells. Spectrin forms pentagonal or hexagonal arrangements, forming scaffolding and playing an important role in maintenance of plasma membrane integrity and cytoskeletal structure (27); interacts with Epb41l1]. |
Tenm3 | Integral membrane protein involved in development. Promotes homophilic cell adhesion. May function as a cellular signal transducer. |
Square brackets indicate additional material culled from the literature.