Table 9.
β-Catenin-interacting proteins: vasopressin responses in prior studies
| Gene Symbol | Annotation | Regulation by Vasopressin |
|---|---|---|
| Ctnna1 | Catenin alpha-1 | dDAVP at a concentration of 0.1 nM for 1 h increases abundance of Ctnna1 in nuclear pellet of mouse mpkCCD to 150% (62). dDAVP at a concentration of 1 nM for 0–15 min decreases phosphorylation of Ctnna1 protein at S643 protein in rat IMCD to 70% (26). |
| Ctnnd1 | Catenin delta-1 | Ctnnd1 protein undergoes a reciprocal abundance change in the 17,000 g membrane fraction [down] and the 1,000-g pellet fraction [up] in response to vasopressin (81). dDAVP at a concentration of 0.1 nM for 1 h increases phosphorylation of Ctnnd1 protein at S862 in nuclear pellet of mouse mpkCCD to 460% (5). dDAVP at a concentration of 0.1 nM for 1 h increases phosphorylation of Ctnnd1 protein at S864 in nuclear pellet of mouse mpkCCD to 350% (5). dDAVP at a concentration of 1 nM for 0.5 h decreases phosphorylation of Ctnnd1 protein at S899 in mouse mpkCCD to 80% (58). |
| Cdh1 | Cadherin-1 | Cdh1 protein undergoes a reciprocal abundance change in the 200,000-g cytosolic fraction [down] and the 1,000-g pellet fraction [up] in response to vasopressin (81). |
| Lama1 | Laminin subunit alpha-1 | None |
| Hspd1 | 60 kda heat shock protein, mitochondrial | None |
| Tenm3 | Teneurin-3 | None |
| Plekha6 | Pleckstrin homology domain-containing family A member 6 | dDAVP at a concentration of 1 nM for 0–15 min increases phosphorylation of Plekha6 at S970 in rat IMCD to 140% (26). |
| Akr1b1 | Aldose reductase | dDAVP at a concentration of 5 ng/h to rats for 72 h decreases abundance of Akr1b1 protein in rat IMCD to 50% (73). |
| Lrba | Lipopolysaccharide-responsive and beige-like anchor protein | dDAVP at a concentration of 5 ng/h to rats for 72 h decreases abundance of Lrba protein in rat IMCD to 70% (56). dDAVP at a concentration of 0.1 nM for 120 h decreases abundance of Lrba protein in mouse mpkCCD to 80% (35). dDAVP at a concentration of 1 nM for 0–15 min increases phosphorylation of Lrba protein at T1231 protein in rat IMCD to 140% (26). |
| Tpi1 | Triosephosphate isomerase | dDAVP at a concentration of 5 ng/h to rats for 72 h decreases abundance of Tpi1 protein in rat IMCD to 40% (56). |
| Sptbn2 | Spectrin beta chain, non-erythrocytic 2 | Sptbn2 protein undergoes a reciprocal abundance change in the 200,000-g cytosolic fraction [down] and the 1,000-g pellet fraction [up] in response to vasopressin (81). dDAVP at a concentration of 5 ng/h to rats for 72 h increases abundance of Sptbn2 protein in rat IMCD to 160% (56). |
| Tdrd3 | Tudor domain-containing protein 3 | None |
| Taf1 | Transcription initiation factor TFIID subunit 1 | None |
| Vcl | Vinculin | dDAVP at a concentration of 0.1 nM for 120 h decreases abundance of Vcl protein in mouse mpkCCD to 80% (35). |
| Hspb1 | Heat shock protein b-1 | dDAVP at a concentration of 5 ng/h to rats for 72 h increases abundance of Hspb1 protein in rat IMCD to 250% (56). dDAVP at a concentration of 1 nM for 0–15 min increases phosphorylation of Hspb1 protein at S13 protein in rat IMCD to 120% (26). dDAVP at a concentration of 1 nM for 0–15 min increases phosphorylation of Hspb1 protein at S85 protein in rat IMCD to 130% (26). |
| Fat1 | Protocadherin Fat 1 | None |
| Epb41l1 | Band 4.1-like protein 1 isoform S | None |
| Afdn | Afadin | None |
| Ugt1a5 | UDP-glucuronosyltransferase 1–5 | None |
| Pkp2 | Plakophilin-2 | dDAVP at a concentration of 0.1 nM for 1 h increases abundance of Pkp2 in nuclear pellet of mouse mpkCCD to 200% (62). Pkp2 protein undergoes a reciprocal abundance change in the 17,000-g membrane fraction [down] and the 1,000-g pellet fraction [up] in response to vasopressin (81). Pkp2 protein half-life increases from 17.5 to 29.0 h in mouse mpkCCD cells in response to vasopressin (61). |
| Pithd1 | PITH domain-containing protein 1 | None |
| Etl4 | Sickle tail protein homolog | None |
| Mdh2 | Malate dehydrogenase, mitochondrial | None |
| Dnhd1 | Dynein heavy chain domain-containing protein 1 | None |
| Hnrnpm | Heterogeneous nuclear ribonucleoprotein M | None |
| Ahnak | Neuroblast differentiation-associated protein AHNAK | Ahnak protein undergoes a reciprocal abundance change in the 200,000-g cytosolic fraction [down] and the 1,000-g pellet fraction [up] in response to vasopressin (81). dDAVP alters phosphorylation of Ahnak at multiple sites in rat IMCD (26). dDAVP at a concentration of 0.1 nM for 1 h increases abundance of Ahnak in nuclear pellet of mouse mpkCCD to 150% (62). dDAVP aalters phosphorylation of Ahnak protein at multiple sites in nuclei of mouse mpkCCD (5). |
| Ccdc130 | Coiled-coil domain-containing protein 130 | None |
| Tns3 | Tensin-3 | dDAVP at a concentration of 1 nM for 0–15 min increases phosphorylation of Tns3 protein at S864 protein in rat IMCD to 260% (26). |
| Lgr4 | Leucine-rich repeat-containing G-protein coupled receptor 4 | None |
| Cenpj | Centromere protein J | None |
| Jup | Junction plakoglobin | dDAVP at a concentration of 0.1 nM for 1 h increases abundance of Jup in nuclear pellet of mouse mpkCCD to 160% (62). Jup protein undergoes a reciprocal abundance change in the 17,000-g membrane fraction [down] and the 1,000-g pellet fraction [up] in response to vasopressin (81). Jup protein half-life increases from 13.3 to 23.6 h in mouse mpkCCD cells in response to vasopressin (61). dDAVP at a concentration of 0.1 nM for 1 h increases phosphorylation of Jup protein at S665 in nuclear pellet of mouse mpkCCD to 150% (5). dDAVP at a concentration of 0.1 nM for 120 h decreases translation rate of Jup protein in mouse mpkCCD to 50% (61). |
| Plec | Plectin | dDAVP at a concentration of 0.1 nM for 1 h increases abundance of Plec in nuclear pellet of mouse mpkCCD to 150% (62). dDAVP at a concentration of 1 nM for 0–15 min decreases phosphorylation of Plec protein at S21 protein in rat IMCD to 80% (26). dDAVP at 0.5 ng/h for 7 days increases mRNA abundance of Plec in AQP1 KO mouse renal inner medulla to 150% (7). |
| Itga1 | Integrin alpha-1 | Itga1 protein half-life decreases from 52.8 to 10.6 h in mouse mpkCCD cells in response to vasopressin (61). |
| Alpk1 | Alpha-protein kinase 1 | None |
| Ppl | Periplakin | dDAVP at a concentration of 0.1 nM for 1 h increases abundance of Ppl in nuclear extract of mouse mpkCCD to 170% (62). Ppl protein undergoes a reciprocal abundance change in the 200,000-g cytosolic fraction [down] and the 1,000-g pellet fraction [up] in response to vasopressin (81). AVP at 10 nM for 4 h decreases mRNA abundance of Ppl in mouse mpkCCDcl4 (SAGE) to 0% (59). dDAVP at a concentration of 1 nM for 0.5 h decreases phosphorylation of Ppl protein at S14 in mouse mpkCCD to 20% (5). |
| Krt4 | Keratin, type II cytoskeletal 4 | None |
| Krt76 | Keratin, type II cytoskeletal 2 | None |
| Hist1h4b | Histone H4 | None |
| H1f0 | Histone H1.0 | dDAVP at a concentration of 0.1 nM for 120 h decreases abundance of H1f0 protein in mouse mpkCCD to 70% (35). |
| H2afz | Histone H2A.Z | None |
| Krt19 | Keratin, type I cytoskeletal 19 | dDAVP at a concentration of 5 ng/h to rats for 72 h increases abundance of Krt19 protein in rat IMCD to 170% (56). dDAVP at a concentration of 1 nM for 0–15 min increases phosphorylation of Krt19 protein at S67 protein in rat IMCD to 150% (26). dDAVP at a concentration of 0.1 nM for 1 h increases phosphorylation of Krt19 protein at S67 in nuclear pellet of mouse mpkCCD to 400% (5). dDAVP at a concentration of 0.1 nM for 1 h increases phosphorylation of Krt19 protein at S67 in nuclear extract of mouse mpkCCD to 280% (5). |
| Krt28 | Keratin, type I cytoskeletal 28 | None |
Data mined from prior publications using Biological Information Gatherer (BIG) (see methods).