Skip to main content
. 2017 Mar 22;313(1):F116–F125. doi: 10.1152/ajprenal.00048.2017

Fig. 3.

Fig. 3.

Urinary ammonia and acid excretion response to dietary protein restriction in PT-GS-KO mice. A: changes in urinary ammonia excretion. In the animals fed 20% protein diet, there were no significant time-dependent changes in urinary ammonia excretion. In mice fed 6% protein diet, urine ammonia excretion decreased and was significantly different from in mice fed 20% protein diet (P < 0.005). Thus, the changes in ammonia excretion in PT-GS-KO mice in response to dietary protein restriction are specific to the change in protein intake and are not a nonspecific time-dependent change. *P < 0.05 vs. 20% protein diet on individual day; n = 5 and 6 for 20% and 6% protein diets, respectively. B: changes in urine pH. There were no significant changes in urine pH in time-control studies of PT-GS-KO mice fed 20% protein diet. In mice fed 6% protein diet, urine pH was significantly different from in mice fed 20% protein diet (P < 0.005). *P < 0.05 vs. 20% protein diet in PT-GS-KO mice on an individual day; n = 5 and 6 for 20% and 6% protein diets, respectively. C: titratable acid excretion. There were no time-dependent changes in titratable acid excretion in PT-GS-KO mice fed 20% protein diet and 6% protein diet; n = 5, 20% protein diet and n = 6, 6% protein diet.