Table 1.
Physiological parameters during dietary protein restriction
| Parameter | Control | PT-GS-KO | P Value |
|---|---|---|---|
| Mean daily body wt, g/day | 32.2 ± 0.6 (12) | 32.7 ± 0.9 (12) | NS |
| Mean daily food intake, g/day | 5.9 ± 0.1 (12) | 5.7 ± 0.2 (12) | NS |
| Serum Na+, mmol/l | 150.5 ± 1.0 (12) | 151.4 ± 1.1 (9) | NS |
| Serum K+, mmol/l | 3.88 ± 0.08 (12) | 3.84 ± 0.14 (9) | NS |
| Serum , mmol/l | 21.9 ± 0.5 (12) | 21.9 ± 0.7 (12) | NS |
| Blood urea nitrogen, mg/dl | 20.3 ± 3.0 (6) | 19.0 ± 0.9 (4) | NS |
Values ae means ± SE; nos. in parentheses are no. of animals in each group. PT-GS-KO, proximal tubule-specific glutamine synthetase deletion; NS, not significant.