| Apoptosis |
MCL1 amplification |
| Cell cycle regulation |
CDKN2A/B loss, SOX2 amplification |
| CDK12 Q570*, CCND1 amplification |
| FGF19 amplification, FGF3 amplification |
| FGF4 amplification, CCNE1 amplification |
| CCND1 amplification, SMARCB1 I365fs*22+ |
| Epigenetic regulation |
MLL2 R4904*, KDM6A S466 |
| ARID1A Y1211fs*5, S1929fs*25, and E2250fs*28 |
| SETD2 G1644*, N2071fs*17 |
| ATRX R840fs*29, CREBBP S893L |
| PI3K/AKT/mTOR pathway signaling |
PIK3CA H1047R, Q75E, E545K, and amplification |
| FBXW7 splice 726+1 G>A, R465H, and W244 |
| MAPK pathway signaling |
KRAS amplification, FGFR1 amplification |
| Transcription regulation |
MYCL1 amplification, MYST3 amplification |
| EWSR1 EWSR1-CREB1 fusion, EMSY amplification |
| SMAD4 P130S, NFE2L2 D11Y |
| ETV1 rearrangement, NOTCH1 APIP-NOTCH1 fusion |
| Tumor suppressor |
MDM4 amplification, MDM2 amplification |
| TP53 L45P, Q38fs*79, R273C, R248Q, R196*, and R248W |
| Wnt signaling |
CDC73 Q333*, CTNNB1 S33P |
