Table 1.
Region II-plus sequences of CS and homologous sequences of SSP2/TRAP from several species of malaria parasitesa
| Malaria parasite | Region II-plus sequencesb |
|---|---|
| Circumsporozoite protein | |
| Plasmodium falciparum | EWSPCSVTCGNGIQVRIK |
| Plasmodium vivax | EWTPCSVTCGVGVRVRRR |
| Plasmodium malariae | EWSPCSVTCGSGIRARRK |
| Plasmodium knowlesi | EWTPCSVTCGNGVRIRRK |
| Plasmodium cynomolgi | EWSPCSVTCGKRVRMRRK |
| Plasmodium brasilianum | EWSPCSVTCGKRVRMRRK |
| Plasmodium berghei | EWSPCSVTCGSGIRARRK |
| Plasmodium yoelii | EWSQCNVTCGSGIRVRKR |
| SSP2/TRAP | |
| Plasmodium falciparum | EWSPCSVTCGKGTRSRKR |
| Plasmodium yoelii | EWSECSTTCDEGRKIRRR |
a
Abbreviations: CS, circumsporozoite protein; SSP2, sporozoite surface protein 2; TRAP, thrombospondin-related adhesion protein.
b
The highly conserved cysteines and the downstream basic residues that are essential for binding to heparan sulfate proteoglycans are marked in bold.