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(A) Change in the percentage of mouse body weights, pre- and post-treatment, in the listed groups and cohorts. (B) Mouse toxicity tests, consisting of BUN, AST and ALT in the listed groups. (C) Hematoxylin and eosin, and Kras immunostaining of the listed organs in KTC (early) mice. Three to five mice evaluated per organ, one-way ANOVA. The data is presented as the mean ± SEM. See accompanying source data.
