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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Psychopharmacology (Berl). 2017 Apr 18;234(16):2385–2398. doi: 10.1007/s00213-017-4629-2

Figure 1. HDAC inhibitors decrease HAL-induced motor side effect severity in aged mice.

Figure 1

Panel A–C: HAL induces motor deficits in a dose-dependent manner, which are exaggerated in aged mice. Panel D–F: HDAC inhibitors VPA and MS-275 reverse motor-side effects induced by HAL. Catalepsy (A,D), measured as the duration of cataleptic episodes in seconds. Rotarod (B,E), measured as the latency to fall from the rod. Open field, measured as general motor movement (C,F). Data represent mean ± S.E.M. (n = 6–8/group). *p<0.05, **p<0.01, ***p<0.001.