Table 2.
Characterization of P-MORF2 conjugates.
| No. | Polymer-MORF2 conjugatea | Polymer precursor | Conjugate | ||||
|---|---|---|---|---|---|---|---|
|
|
|
||||||
| Mn (kDa) | PDI | Mn (kDa)b | PDI | Valencec | |||
| 1a | P1-(MORF2)2.6 | P1-TT | 87 | 1.18 | 109 | 1.36 | 2.6 |
| 1b | P1-(MORF2)4.0 | P1-TT | 87 | 1.18 | 121 | 1.34 | 4.0 |
| 1c | P1-(MORF2)11.4 | P1-TT | 87 | 1.18 | 183 | 1.34 | 11.4 |
| 2a | P1-(MORF2-20 bp)13.5 | P1-TT | 87 | 1.18 | 179 | 1.31 | 13.5 |
| 2b | P1-(MORF2-28 bp)10.6 | P1-TT | 87 | 1.18 | 187 | 1.41 | 10.6 |
| 3a | P2-(PEG2-MORF2)12.7 | P2-mal | 112 | 1.17 | 219 | 1.36 | 12.7 |
| 3b | P2-(PEG8-MORF2)11.2 | P2-mal | 112 | 1.17 | 207 | N/D | 11.2 |
| 4a | P3-(PEG2-MORF2)13.7 | P3-mal | 291 | 1.17 | 407 | N/D | 13.7 |
| 4b | P3-(PEG2-MORF2)25.1 | P3-mal | 291 | 1.17 | 503 | N/D | 25.1 |
a
If not otherwise stated, MORF2 oligos were 25 base pairs (bp).
b
Number average molecular weight (Mn) was calculated from the molecular weight of the polymer precursor and the content of MORF2 as determined by UV–visible spectrophotometry.
c
MORF2 per polymer chain as determined by UV–visible spectrophotometry.