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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: J Steroid Biochem Mol Biol. 2017 Feb 1;173:157–167. doi: 10.1016/j.jsbmb.2017.01.024

Figure 5. Multiple regions of RIPK1 mediate its binding to VDR.

Figure 5

A. Schematic representation of the domain structure of RIPK1 and its deletion constructs. Amino acid residue numbers are shown at the top of the graphs. KD: kinase domain (aa.1-289); ID: Intermediate domain (aa.290-583); IDs: Smaller ID (aa.290-547); ΔKD: Kinase deleted (aa.290-583). B. 293T cells were transfected with 1.5 μg of Flag-VDR together with 1.5 μg of full-length (FL) or deletion constructs of HA-RIPK1 as indicated. Cellular extracts were subjected to co-immunoprecipitation analyses with antibodies as indicated.