Table 1.
Baseline characteristics
| Characteristics * | ALL (N=8,164) | Intensive Arm (N=4,086) | Standard Arm (N=4,078) | P-value † |
|---|---|---|---|---|
| Age (years) | 67.9 ± 9.3 | 67.9 ± 9.2 | 67.8 ± 9.3 | 0.87 |
| Age≥75 years | 2249 (27.5) | 1131 (27.7) | 1118 (27.4) | 0.79 |
| Sex (women) | 2879 (35.3) | 1455 (35.6) | 1424 (34.9) | 0.51 |
| Black | 2551 (31.2) | 1253 (30.7) | 1298 (31.8) | 0.26 |
| Smoking | 0.71 | |||
| Former smoker | 3482 (42.7) | 1730 (42.3) | 1752 (43.0) | |
| Current smoker | 1050 (12.9) | 539 (13.2) | 511 (12.5) | |
| Body mass index (kg/m2) | 29.9 ± 5.7 | 30.0 ± 5.8 | 29.8 ± 5.6 | 0.16 |
| Systolic BP (mmHg) | 139.5 ± 15.5 | 139.4 ± 15.7 | 139.6 ± 15.3 | 0.56 |
| Diastolic BP (mmHg) | 78.1 ± 11.8 | 78.2 ± 11.8 | 78.1 ± 11.9 | 0.66 |
| Systolic BP tertiles | 0.24 | |||
| ≤ 132 mm Hg | 2747 (33.6) | 1402 (34.3) | 1345 (33.0) | |
| >132 to< 145 mm Hg | 2669 (32.7) | 1302 (31.9) | 1367 (33.5) | |
| ≥ 145 mm Hg | 2748 (33.7) | 1382 (33.8) | 1366 (33.5) | |
| Number of BP medications | 1.8 (1.0) | 1.8 (1.0) | 1.8 (1.0) | 0.21 |
| Not using BP medications | 778 (9.5) | 376 (9.2) | 402 (9.9) | 0.31 |
| Serum creatinine (mg/dL) | 1.07 ± 0.33 | 1.07 ± 0.34 | 1.07 ± 0.33 | 0.88 |
| Urine albumin/creatinine (mg/g) | 38.9 ± 138.2 | 40.3 ± 147.5 | 37.5 ± 128.2 | 0.37 |
| Chronic kidney disease ‡ | 2259 (27.7) | 1157 (28.3) | 1102 (27.0) | 0.19 |
| Total cholesterol (mg/dL) | 190.1 ± 41.2 | 190.2 ± 41.6 | 190.0 ± 40.8 | 0.84 |
| HDL-cholesterol (mg/dL) | 52.8 ± 14.4 | 52.8 ± 14.3 | 52.8 ± 14.4 | 0.98 |
| Triglycerides (mg/dL) | 126.0 ± 91.0 | 126.8 ± 88.7 | 126.2 ± 93.2 | 0.75 |
| Fasting plasma glucose (mg/dL) | 98.9 ± 13.4 | 99.0 ± 13.7 | 98.7 ± 13.1 | 0.44 |
| History of prior CVD | 1618 (19.8) | 814 (19.9) | 804 (19.7) | 0.82 |
| Cornell voltage LVH | 605 (7.4) | 302 (7.4) | 303 (7.4) | 0.95 |
BP= blood pressure; HDL= high density lipoprotein; CVD= cardiovascular disease; LVH= left ventricular hypertrophy
*
Data are presented as number (%) or mean ± standard deviation
†
p-value comparing participants’ characteristics in the standard vs. intensive blood pressure-lowering arms
‡
Defined as baseline estimated glomerular filtration rate< 60 ml/min/1.73m2