Skip to main content
. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Psychopharmacology (Berl). 2017 May 2;234(16):2431–2441. doi: 10.1007/s00213-017-4632-7

Fig. 4.

Fig. 4

AI neural inactivation following cocaine memory reactivation does not alter subsequent drug context-induced reinstatement of extinguished cocaine-seeking behavior. (a) Schematic depicting the timeline for Experiment 2. (b) Active and (d) inactive lever responses (mean ± SEM) during self-administration training (SA, mean of last three 2-h sessions), during the 15-min memory reconsolidation session (MR, 15-min session), during extinction training in the extinction context (EXT, last 2-h session following MR), and at testing in the cocaine-paired context (COC-paired, 2-h session) for rats that had received VEH (white bars/symbols) or BM (1.0+0.1 mM/0.5 µl per hemisphere; black bars/symbols) into the AI immediately after the memory reactivation session. Time course of (c) active and (e) inactive lever responses (mean ± SEM/20 min) at test. Symbols represent difference relative to the EXT context (* a: ANOVA context main effect, P = 0.0001; b: ANOVA context main effect, P = 0.04) or relative to the first 20-min interval (# Tukey’s test, P < 0.01).