Figure 4.

Regrowth of tumors after drug and/or radiation treatment. Tumor volumes are normalized to volume at the start of the experiment. (A) Untreated tumors (n = 6) (B) Treated with evofosfamide (1 × 100 mg/kg) (n = 7) (C) Treated with 15 Gy (n = 6) (D) Evofosfamide administered 3 hours prior to 15 Gy. (n = 7) Dashed lines represent a threefold increase in tumor volume, which was selected as the endpoint to generate (E) P values calculated from the Mann Whitney test. The controls were significantly different from all the treated groups (vs Rad, 0008; Evofos, 0.012; Combined, 0.0013). The combined therapy was significantly more effective than evofosfamide alone.