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. 2017 Aug 1;7:6975. doi: 10.1038/s41598-017-07308-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Active immunization of modified NS1-WD peptide protects mice against DENV–elicited hemorrhage and coagulopathy. Disease mouse model was created as described in the Methods (N = 5 for each group). (A) The tail bleeding time was determined on day 3. (B) The clinical score of hemorrhage was quantified and determined as digital hemorrhage severity by ImageJ. (C) H&E staining was performed to analyze local skin hemorrhage in the skin lesions. The yellow arrows indicate the intact blood vessels. The scale bar indicated 40 μm. (D) DENV NS3 expression (green staining) and complement c1q deposition (brown staining) were depicted in IHC double staining. Red arrows indicate local DENV NS3 expression, and red stars indicate c1q deposition. The scale bar indicates 40 μm. *P < 0.05, **P < 0.01, ***P < 0.001, ns indicates no significance.