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. 2017 Aug 1;7:6975. doi: 10.1038/s41598-017-07308-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Antibodies bind to modified NS1-WD peptide in dengue patients. (A) The OD of antibodies against NS1, modified NS1-WD peptide-conjugated BSA, C terminal NS1 (a.a. 305–314)-conjugated BSA and control peptide (Nonspecific peptide)-conjugated BSA in the sera of dengue patients (N = 67), as well as healthy donors (N = 26), was determined by ELISA. (B) The correlation of the OD of anti-NS1 (x-axis) and anti-modified NS1-WD peptide (y-axis) antibodies in the sera of dengue patients (N = 67). (C) The OD ratio of Abs binding to modified NS1-WD peptide to total NS1 Abs was significantly reduced in severe dengue patients’ sera (N = 17) compared to dengue with (N = 20) or without (N = 30) warning signs. *p < 0.05, **p < 0.01, ***p < 0.001. (D) The comparison of the OD of total NS1 Abs in dengue patients with different disease severity.