Table 5.
Representative biological processes and anatomic localizations within the two gene coexpression modules.
| Module | Biological Process | Genes |
|---|---|---|
| Collagen Module | Collagen Catabolism | COL17A1; PRTN3; MMP8; MMP9; ELANE |
| Cell surface interactions at the vascular wall | CEACAM1; CEACAM6; OLR1; CEACAM8 | |
| Host responses to bacterial pathogens | CEBPE; ANXA3; DEFA4; HP; DEFA3; RNASE3; DEFA1; AZU1; BPI; PGLYRP1; CAMP; ELANE; LTF | |
| Mucosal innate immunity | DEFA3; RNASE3; DEFA1; CAMP; LTF | |
| Anatomical localization | Genes | |
| Extracellular space | SERPINB10; ORM1; ARG1; DEFA4; CRISP3; HP; DEFA3; DEFA1; RNASE3; MMP8; OLFM4; MMP9; MPO; TCN1; LCN2; CHI3L1; PRTN3; CTSG; CEACAM8; CAMP; LTF | |
| Extracellular matrix | SLPI; CRISP3; TFF3; CHI3L1; PRTN3; CTSG; DEFA1; MMP8; MMP9 | |
| Platelet Module | Transcription regulation | SCL; GATA1; HNF4A; FLI1; EGR1; SOX2; ATF3; RUNX1; GATA2; MITF; TAL1 |
| Coagulation and hemostasis | GUCY1B3; SPARC; ITGB3; PROS1; ITGA2B; MPL; F13A1; TFPI; THBS1; GRB14; HMG20B; JAM3; P2RY12; GUCY1A3; ABCC4; VWF; EGF; ACTN1; GP1BA; ANO6; PPBP; GP6; PTK2; TUBA4A; SELP; GP9; EHD3; KIF2A; MMRN1; CD9; PDE5A; ESAM; MGLL; VCL | |
| Platelet activation, aggregation, and signaling. | SPARC; ITGB3; PROS1; ITGA2B; MPL; F13A1; THBS1; GNG8; P2RY12; ABCC4; VWF; EGF; ACTN1; GP1BA; PPBP; GP6; GNG11; PTK2; TUBA4A; SELP; GP9; MMRN1; CD9; MGLL; VCL |