Table 7.
Cognitive ability | APOE rs429358 | P-value | APOE rs7412 | P-value | ||
---|---|---|---|---|---|---|
(T/T) (n = 760) | (C/T) (n = 154) | (C/C) (n = 772) | (C/T) (n = 142) | |||
Visual and executive | 3.92 (3.84, 4.01) | 3.80 (3.62, 3.99) | 0.244 | 3.93 (3.85, 4.01) | 3.76 (3.57, 3.95) | 0.108 |
Naming | 2.92 (2.89, 2.95) | 2.83 (2.76, 2.90) | 0.015 | 2.91 (2.88, 2.94) | 2.89 (2.82, 2.96) | 0.563 |
Attention | 5.34 (5.26, 5.42) | 5.31 (5.13, 5.49) | 0.803 | 5.36 (5.28, 5.44) | 5.21 (5.02, 5.40) | 0.158 |
Language | 2.24 (2.18, 2.30) | 2.11 (1.98, 2.24) | 0.086 | 2.23 (2.17, 2.29) | 2.16 (2.02, 2.29) | 0.350 |
Abstraction | 1.65 (1.60, 1.70) | 1.59 (1.48, 1.70) | 0.359 | 1.65 (1.60, 1.70) | 1.59 (1.48, 1.70) | 0.358 |
Memory and delayed recall | 3.09 (2.99, 3.20) | 2.91 (2.68, 3.13) | 0.145 | 3.09 (2.99, 3.19) | 2.91 (2.67, 3.14) | 0.165 |
Orientation | 5.81 (5.75, 5.87) | 5.65 (5.52, 5.78) | 0.029 | 5.79 (5.73, 5.85) | 5.76 (5.62, 5.90) | 0.685 |
MoCA score | 25.25 (24.93, 25.57) | 24.50 (23.79, 25.21) | 0.060 | 25.23 (24.91, 25.54) | 24.52 (23.77, 25.26) | 0.087 |
Data were expressed as mean (95% CI). General Line Model (GLM) was used for data analysis. Factors including sex, age, BMI, education, smoking, alcohol drinking and physical activity levels were adjusted. P-value < 0.05 was considered as significance. ApoE, Apolipoprotein E.