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. 2017 Aug 2;9:253. doi: 10.3389/fnagi.2017.00253
Level 1:        yijk = π0jk + π1jk(T1) + π2jk(T2) + π3jk(T3)
         + π4jk (T4) + π5jk (T5) + eijk
Level 2: π0jk = β00k + r0jk
π1jk = β10k
π2jk = β20k
π3jk = β30k
π4jk = β40k
π5jk = β50k
Level 3: β00k = γ000 + u00k
β10k = γ100 + u10k
β20k = γ200 + u20k
β30k = γ300 + u30k
β40k = γ400 + u40k
β50k = γ500 + u50k