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. 2017 Aug 2;5:58. doi: 10.3389/fchem.2017.00058

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Copyright © 2017 Ayaz, Junaid, Ullah, Sadiq, Shahid, Ahmad, Ullah, Ahmad and Syed.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gastroprotective effect of Ph.Cr extract in the aspirin induced ulcerogenesis in pylorus ligated rat model (H & E staining, ×100 original magnification) (n = 6 each). (A) Photomicrograph of a section of glandular portion of stomach from a vehicle treated control rat showing normal histological appearance of mucosa (M), submucosa (SM), and muscularis externa (ME). (B) Photomicrograph of a section of stomach glandular tissue from a rat treated with aspirin (200 mg/kg) showing disruption and erosion (arrows) of mucosa (M) which extend to the submucosa (SM) and muscularis externa (ME) along with necrotic debris visible in the lumen (asterisk) and base of the ulcer. Normal histoarchitecture of gastric mucosa (M), sub-mucosa (SM) and muscularis externa (ME) was observed in groups of rats treated with (C) positive control, ranitidine (50 mg/kg), (D) Ph.Cr extract at 100 mg/kg except for mild superficial shredding of surface mucosal epithelium (arrow), (E) Ph.Cr extract at 200 mg/kg, and (F) Ph.Cr extract at 400 mg/kg.