Table 3.

Gastroprotective effect of Ph.Cr extract in the aspirin induced ulcerogenesis in pylorus ligated rat model.

Groups	Ulcer score	Gastric juice volume (mL)	Gastric juice pH	Free acidity (mEq/L)	Total acidity (mEq/L)	Pepsin (μg/mL)
Vehicle	0.167 ± 0.1054	2.345 ± 0.2451	3.030 ± 0.2026	25.50 ± 2.262	42.17 ± 3.301	9.625 ± 0.5186
Aspirin (200 mg/kg)	3.500 ± 0.6055***	5.007 ± 0.5237***	1.360 ± 0.1699***	42.67 ± 3.896**	59.67 ± 5.439*	13.19 ± 1.068*
Ranitidine (50 mg/kg)	1.167 ± 0.3575	2.782 ± 0.2709	2.563 ± 0.3546	28.50 ± 3.149	46.67 ± 3.584	10.75 ± 0.9471
Ph.Cr (100 mg/kg)	1.917 ± 0.5069*	3.513 ± 0.3279	1.880 ± 0.1688*	33.00 ± 2.852	51.67 ± 3.051	11.06 ± 0.9297
Ph.Cr (200 mg/kg)	1.333 ± 0.4773	3.110 ± 0.2832	2.337 ± 0.2714	29.50 ± 2.643	48.50 ± 3.423	10.14 ± 0.8003
Ph.Cr (400 mg/kg)	0.917 ± 0.3005	2.642 ± 0.2670	2.663 ± 0.2813	27.33 ± 2.333	43.33 ± 3.913	10.02 ± 0.6426

Values expressed as mean ± SEM.

^*P < 0.05,

^**P < 0.01,

^***P < 0.001, compared to vehicle treated control (one-way ANOVA followed by Dunnett's post-hoc test), n = 6 rats per group.