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NOD2 genotypes and clinical course in SC-CIP patients (Cohort 1).
| NOD2 status | Wild-type | Variants* |
|---|---|---|
| Patients (%) | 12/17 (70.6%) | 5/17 (29.4%) |
| Cholangitis | 4/12 (33.3%) | 4/5 (80.0%) |
| Sepsis | 7/12 (58.3%) | 3/5 (60.0%) |
| Progression to cirrhosis | 5/12 (41.7%) | 3/5 (60.0%) |
| Liver transplantation | 0 | 2/5 (40.0%) |
| Death | 3/12 (25%) | 0 |
*4 patients were carriers of the NOD2 variant p.R702W, and one patient carried
the c.3020insC variant, all in heterozygous state.
