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. 2017 Aug 2;4:43. doi: 10.3389/fcvm.2017.00043

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Copyright © 2017 Delbosc, Bayles, Laschet, Ollivier, Ho-Tin-Noé, Touat, Deschildre, Morvan, Louedec, Gouya, Guedj, Nicoletti and Michel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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High-cholesterol diet induces red blood cell accumulation in rabbit foam cells. (A) After consuming a hypercholesterolemic diet for 3 months, rabbits showed significantly increased percentages of circulating Annexin V⁺ RBCs (***p < 0.001; Mann–Whitney’s test). (B) The consumption of a hypercholesterolemic diet was associated with the development of focal subendothelial lesions characterized by the predominance of foam cells, as shown by Masson’s trichrome staining. These foam cells were redox-active iron-positive based on Perls + DiAminoBenzidin (DAB) staining (Perls alone and DAB alone were strictly negative, not shown). They were also recognized by a rabbit RBC membrane marker (GSL-B4 lectin) and were found to express a phagocyte marker (RAM11).