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. 2017 Aug 2;8:908. doi: 10.3389/fimmu.2017.00908

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Copyright © 2017 Forget, Tavera, Haymaker, Ramachandran, Malu, Zhang, Wardell, Fulbright, Toth, Gonzalez, Thorsen, Flores, Wahl, Peng, Amaria, Hwu and Bernatchez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic of Rapid Expansion Protocol (REP) with transduction of tumor-infiltrating lymphocyte (TIL). TIL are thawed on day −5 and allowed to rest for 2 days. The resting period is followed by activation of the TIL with plate-bound anti-CD3 on day −3 and transduction is performed on day −1. Finally, the REP process is followed from days 0 to 14 with the exception that we omit the initial anti-CD3 stimulation on day 0. Genetically modified TIL are harvested and infused fresh on day 14 of the REP.