Table 1.
Summary of effects of cannabinoid drugs on the CSI.
| Drug | n | CSI | ||
|---|---|---|---|---|
| # neurons with significant change | Total change | Segregated changes | ||
| Anandamide (agonist) | 50 | 23 | ↓ 0.42 to 0.32 (P = 0.048) (parametric test) | 16/23 ↓ 0.51 to 0.27 (P < 0.001) (non-parametric test) |
| 7/23 ↑ 0.22 to 0.44 (P = 0.008) (parametric test) | ||||
| O-2545 (agonist) | 40 | 13 | ↓ 0.53 to 0.29 (P = 0.012) (parametric test) | 11/13 ↓ 0.61 to 0.31 (P = 0.003) (parametric test) |
| 2/13 ↑ 0.21 to 0.4 (no statistical analysis) | ||||
| AM251 (antagonist | 49 | 7 | ↑ 0.17 to 0.43 (P = 0.017) (parametric test) | N/A* |
*N/A Does not apply.