Table 1.

In vitro inhibitory potency and selectivity of 2-oxoesters.

Entry	No	Structure	GIVA cPLA2		GVIA iPLA2		GV sPLA2	ClogP
			% Inhibitiona	X I(50)	% Inhibitiona	X I(50)	% Inhibitiona
1	10e		68.2 ± 2.7		69.4 ± 12.2		27.5 ± 0.9	6.51
2	12e		78.4 ± 3.5		<25		<25	5.63
3	17a		>95	0.00008 ± 0.00001	<25		<25	6.76
4	20		<25		<25		41.0 ± 0.2	6.82
5	17b		>95	0.00289 ± 0.00043	<25		52.6 ± 5.3	5.46
6	16c		<25		<25		<25	4.58
7	19		27.3 ± 4.8		<25		<25	3.87
8	17d		>95	0.00068 ± 0.00007	<25		<25	4.78
9	17e		> 95	0.00007 ± 0.00001	25		<25	6.68
10	17f		> 95	0.000078 ± 0.00001	65 ± 3.4		<25	4.70
11	17g		> 95	0.0065 ± 0.002	84 ± 1.5		<25	4.25
12	17h		> 95	0.0010 ± 0.0003	94 ± 1.4		<25	4.17
13	10a		<25		72 ± 4		<25
14	10b		55 ± 4.0		> 95	0.0052 ± 0.0007	<25	3.81
15	4		>95	0.00008 ± 0.000005c				8.50

^a% Inhibition at 0.091 mole fraction of each inhibitor. ^bIC₅₀ 4.3 nM in a vesicle assay³².