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. 2017 Aug 1;7:7069. doi: 10.1038/s41598-017-07302-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The real tracking geometry is shown on the left. A 9 cm × 9 cm × 2.2 cm box enclosed the brain volume (9 cm × 9 cm × 9 mm) which was divided into 3 × 3 × 3 mm ³ and the material parametrisation was implemented for all voxels within. In the middle, the RO geometry is shown which consisted of the brain volume enclosing the scoring plane located in the middle of the volume and divided into 20 × 20 × 20 μm ³ (the size of glioma cells). The RO geometry communicates in sync with tracking geometry to score the dose in the cells defined in the scoring plane. On the right, the cross section of the scoring plane is shown. It should be noted that this diagram is not to scale to allow illustration of details.