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. 2017 May 12;148(3):229–238. doi: 10.1007/s00418-017-1578-0

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 7 — E-FABP-immunoreactivity and apoptosis in septoclasts. Confocal laser-scanning micrographs of double staining for E-FABP (red) plus TUNEL reaction (green) at the COJ of the GP in mouse proximal tibiae of P4w control (a), P4w RA excess (b), P9w control (c), and P9w VA deficiency (d) and the graph (e) showing the significant increase of simultaneously E-FABP-immunoreactive and TUNEL-positive apoptotic cells at the COJ of the GP in mouse proximal tibiae of RA excess in an area of 1000-μm width ×200-μm height as compared to the control. Arrows: TUNEL-positive septoclasts; arrow head: TUNEL-positive chondrocyte; scale bars 20 μm; mean ± SD; *P < 0.01 (n = 10)