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. 2017 Apr 10;148(3):313–329. doi: 10.1007/s00418-017-1569-1

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — Numbers of EGFP-positive neurons per brain (N(neurons)) after intracerebral injection of PBjSEW, HIV-2SEW, and HIV-1SEW lentiviral vectors carrying the EGFP reporter gene with or without the accessory proteins Vpx/Vpr. a Overview of all brains under study. b Numbers of transduced neurons were larger after injection of PBjSEW and HIV-1SEW when compared to HIV-2SEW. c Numbers of transduced neurons were larger after injection of HIV-2SEW(Vpx) and HIV-1SEW(Vpr) when compared to PBjSEW(Vpx). d Accessory protein Vpx/Vpr caused significant decrease of neuronal transduction rates for vector PBjSEW but not for the other vectors. Only differences significant at p < 0.05 (*) are shown. Boxes span the interquartile range of data on the y-axis. The inside lines indicate the median and the black diamonds mean values. Whiskers extend to the minimum and maximum values excluding outliers (white circles)