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. 2017 Aug 2;8:557. doi: 10.3389/fphys.2017.00557

Figure 1.

Figure 1

HOXC10 upregulates in human lung cancer tissues. (A) Relative mRNA expression of HOXC10 in human lung cancer (n = 63) and normal (n = 30) tissues was detected by qRT-PCR, GAPDH was used as internal control. (B) Protein expression of HOXC10 in tissues from four represent patients was detected by western blotting; and relative HOXC10 expression was normalized to housekeeping gene GAPDH (C). (D,E) Data was derived from (A), patients were subdivided into two groups according to lymph node (D, N0 and N1-3) or distal metastasis (E, M0 and M1), relative mRNA expression of HOXC10 was compared between these two groups, respectively. (F) The protein expression of HOXC10 in lung cancer tissues with or without metastasis was evaluated by immunohistochemistry. (G) Patients were subdivided into two groups according to the mean value of HOXC10 mRNA expression (cutoff value: 4.219), and survival analysis carried out by the Kaplan-Meier method, and subjected to the log rank test. Data are presented as means ± SD, ***p < 0.0001.