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. 2017 Aug 1;7:7059. doi: 10.1038/s41598-017-07491-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The molecular mechanism of individual response to chemotherapy. Rs3742106 G-allelic ABCC4 disrupts the binding of miR-3190-5p and results in over-expression of ABCC4 and consequent low intracellular concentration of drug, as well as resistance to chemotherapy. On the contrary, the T-allelic ABCC4 generates a binding-site for miR-3190-5p and leads to attenuated expression of ABCC4 protein, elevated intracellular concentration of 5-FU, and increased sensitivity of cells to the chemotherapy.