Figure 2.

Gene ontology enrichment analysis. GO enrichment analysis of host (human) proteins was performed using GOrilla¹⁶ and summarized and visualized as scatter plot using REvigo¹⁷. (Panel a) shows a scatter plot generated in REvigo with the “GO biological terms” clusters remaining after redundancy reduction. (Panel b) shows a scatter plot generated in REvigo with the “GO cellular components clusters” remaining after redundancy reduction. In REvigo the x and y coordinates are derived from a multidimensional scaling to a matrix of the GO terms semantic similarity¹⁷, in such a way that similar terms are located close in the plot. Only those terms with dispensability value equal 0.00 and p value < 0.001 are labelled. Plot colour indicates the enrichment log p value range and the plot size indicates the frequency of the GO term in the database. More general terms are showed with larger symbols.