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. 2017 Aug 1;7:7028. doi: 10.1038/s41598-017-07376-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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mRNA expression levels of hyaluronan-related molecules and proteolytic enzyme of extracellular matrix. mRNA expression of Hyal1(A), KIAA1199(B), HAS1(C), HAS2(D), HAS3(E), MMP-13(F), ADAMTS-5(G) in articular cartilage from 9-month-old male Hyal2 ^−/− and WT mice as determined by real-time PCR amplification (n = 6, respectively). The data presented are the average ± S.D of relative mRNA expression values standardized by Gapdh mRNA expression. *P < 0.05, **P < 0.01.