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. 2017 Aug 1;7:7028. doi: 10.1038/s41598-017-07376-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hyal2 deficiency in cartilage causes the accumulation of high molecular weight hyaluronan. Hyaluronan extracted from knee joints and femoral heads of 9-month-old male mice and hyaluronan references with known molecular sizes were subjected to Sephacryl S-1000 gel filtration chromatography (0.7 × 40 cm). Hyaluronan contents in each fraction were determined using a competitive ELISA. The arrows indicate the positions of peaks of hyaluronan references.