Table 1.
Micro CT analysis at 10 weeks after DMM surgery.
| Parameter | WT DMM (n = 8) | WT Sham (n = 8) | Hyal2 −/− DMM (n = 8) | Hyal2 −/− Sham (n = 8) | WT relative change (%) | Hyal2 −/− relative change (%) |
|---|---|---|---|---|---|---|
| Sb BV/TV (%) | 57.2 ± 8.6* | 44.1 ± 7.5 | 52.0 ± 5.5† | 32.7 ± 10.2‡ | 25.1 ± 4.0 | 59.9 ± 14.0§ |
| Sb Th (μm) | 60.4 ± 3.1* | 52.5 ± 3.5 | 51.3 ± 5.7†¶ | 42.9 ± 7.4‡ | 12.8 ± 7.0 | 24.1 ± 8.7 |
| Tb BV/TV (%) | 41.1 ± 4.2 | 43.7 ± 2.7 | 30.5 ± 5.8¶ | 31.3 ± 7.6‡ | −5.5 ± 7.0 | −2.3 ± 2.6 |
| Tb Th (μm) | 58.2 ± 2.7 | 61.0 ± 6.6 | 50.1 ± 6.5¶ | 52.0 ± 3.6‡ | −3.8 ± 4.6 | −4.9 ± 3.6 |
| Tb Sp (μm) | 101.6 ± 18.0* | 85.2 ± 5.4 | 119.9 ± 14.0†¶ | 99.3 ± 12.7‡ | 19.3 ± 11.2 | 17.9 ± 4.0 |
| Tb.N (/mm) | 7.1 ± 0.8 | 7.9 ± 0.6 | 6.1 ± 1.0¶ | 6.8 ± 1.6‡ | −9.8 ± 8.2 | −11.1 ± 6.4 |
Relative increase of parameters was calculated as follows [(value of DMM – value of Sham) ÷ value of sham × 100%]
*Statistically significant difference between Wild DMM and Wild Sham.
†Statistically significant difference between Hyal2 −/− DMM and Hyal2 −/− Sham.
‡Statistically significant difference between Hyal2 −/− Sham and Wild Sham.
§Statistically significant difference between relative increase Hyal2 −/− and Wild.
¶Statistically significant difference between Hyal2 −/− DMM and Wild DMM.