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. 2017 Aug 2;8:176. doi: 10.1038/s41467-017-00341-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Intraplantar paw injection of Sema4C causes rapid nociceptive sensitization. a A schematic representation of unilateral intraplantar Sema4C application in adult wild-type mice. b Analysis of mechanical sensitivity following a single injection of Sema4C at various doses or vehicle. Response frequency to five applications of von Frey filaments exerting graded force measured at 3 h following Sema4C injection is shown. c Time-course analyses of the effect of a single intraplantar dose of 1 ng Sema4C on sensitivity to 0.07 g of von Frey hair force. d Frequency of paw withdrawal in response to application of 0.07 g force via a von Frey filament upon single intraplantar dose of 1 ng Sema4C in mice lacking Plexin-B2 conditionally in adult DRG (AAV-DRG-PB2^−/−) and their corresponding AAV-DRG-PB2^fl/fl controls (n = 7 mice/group). In all panels, two-way ANOVA for repeated measures followed by Tukey’s test was performed, and P values comparing entire curves are represented. P < 0.05 indicated by * as compared to the corresponding control groups and by ^† as compared to basal. Error bars represent s.e.m