Table 2. Polymorphisms included within the meta-analysis and their association with CRC risk.
Pathway | Gene | rs number | Number of studies | Cases/controls | Wt allele | Minor allele | MAF | Pooled odds ratio | 95% CI | I2 |
---|---|---|---|---|---|---|---|---|---|---|
Base excision repair | APE1 | rs1130409 | 5 | 4,606/5,000 | G | G | 0.3756 | 1.15 | 1.06–1.24 | 36.38 |
MUTYH | rs3219489 | 3 | 5,230/2,756 | G | G | 0.3135 | 1.14 | 0.82–1.58 | 88.23 | |
OGG1 | rs1052133 | 13 | 9,682/1,2938 | C | G | 0.3021 | 1.05 | 0.98–1.11 | 0.00 | |
PARP1 | rs1136410 | 3 | 2,132/4,320 | T | G | 0.1969 | 1.16 | 1.04–1.30 | 15.01 | |
XRCC1 | rs1799782 | 11 | 6,190/10,454 | C | A | 0.1238 | 1.30 | 0.96–1.75 | 86.98 | |
rs25487 | 13 | 7,981/12,226 | G | T | 0.2604 | 1.08 | 0.92–1.26 | 80.55 | ||
rs25489 | 3 | 2,402/3,000 | G | T | 0.0671 | 1.03 | 0.83–1.27 | 0.00 | ||
Homologous recombination repair | RAD18 | rs373572 | 2 | 2,074/2,298 | A | C | 0.3524 | 1.32 | 1.16–1.49 | 0.00 |
RAD51 | rs1801320 | 5 | 1,706/1,240 | G | C | 0.1432 | 0.83 | 0.50–1.38 | 85.96 | |
XRCC3 | rs861539 | 8 | 3,850/4,566 | C | A | 0.2169 | 1.15 | 0.85–1.55 | 82.90 | |
Mismatch repair | MLH1 | rs1799977 | 4 | 8,252/8,802 | A | G | 0.1296 | 1.15 | 0.96–1.37 | 82.88 |
MSH2 | rs2303425 | 2 | 4,598/5,602 | T | C | 0.1008 | 1.06 | 0.94–1.19 | 0.00 | |
MSH6 | rs1042821 | 3 | 6,952/8,174 | C | A | 0.2009 | 0.98 | 0.80–1.20 | 80.04 | |
Nucleotide excision repair | ERCC1 | rs11615 | 4 | 1,890/1,650 | C | A | 0.3311 | 1.03 | 0.90–1.18 | 11.22 |
ERCC5 | rs17655 | 6 | 7,912/8,772 | C | C | 0.3614 | 1.12 | 1.06–1.20 | 0.04 | |
TP53 | rs1042522 | 12 | 8,164/10,176 | C | G | 0.4571 | 1.18 | 0.97–1.45 | 89.23 | |
XPC | rs2228000 | 3 | 3,680/5,212 | C | A | 0.2330 | 1.06 | 0.85–1.32 | 80.80 | |
rs2228001 | 7 | 6,584/8,930 | A | G | 0.3153 | 1.08 | 1.01–1.15 | 49.46 | ||
XPD | rs13181 | 10 | 4,932/6,210 | G | G | 0.2366 | 1.21 | 0.95–1.54 | 85.46 | |
rs1799793 | 3 | 1,520/2,244 | G | T | 0.1954 | 1.13 | 0.87–1.45 | 62.01 | ||
Direct reversal repair | MGMT | rs12917 | 3 | 1,528/3,332 | C | T | 0.1484 | 0.81 | 0.68–0.98 | 0.00 |
rs2308321 | 3 | 1,664/7,016 | A | G | 0.0513 | 0.99 | 0.82–1.19 | 0.00 |
CI, confidence interval; CRC, colorectal cancer; MAF, minor allele frequency; Wt, wild type.
Significant results are in bold.