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. 2017 Jul 14;27(8):959–960. doi: 10.1038/cr.2017.91

Figure 1.

Figure 1

Signaling pathways governing cardiomyocyte proliferation. Left: YAP phosphorylated by Hippo signaling is sequestered by DGC. Myofiber is mature with intact sarcomeric structure. PPARδ/PDK1/AKT/GSK3β/β-cat activity is maintained at basal level. Right: ECM protein agrin binds DGC, which promotes the disassembly of DGC and subsequently myofiber disassembly and YAP activation9,11. Chemical compound carbacyclin increases PPARδ activity, which activates β-cat via PDK1/AKT/GSK3β pathway12. YAP-TEAD and β-cat-TCF promote transcriptional regulation of cardiomyocyte proliferation.