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. 2016 Nov 2;97(1):89–134. doi: 10.1152/physrev.00008.2016

FIGURE 7.

FIGURE 7.

Topology of hERG and KCNE1 in the plasma membrane, representative LQT2- and LQT6-associated mutations highlighted. Different mechanisms of loss of function in hERG or KCNE2, including gating (yellow-filled circle), K+ permeation (black-filled square), trafficking (white-filled triangle), or combined defects (green-filled star) are categorized.

HHS Vulnerability Disclosure