FIGURE 8.
Physiology and molecular biology of INa. A: consecutive recordings of single Na+ channels recorded under cell-attached conditions in HEK293 cells transfected with Nav1.5 cDNA (unpublished data). B: WT Na+ currents recorded under whole cell patch-clamp conditions and obtained by depolarizations from −120 to −30 mV (unpublished data). At high gain (inset), whole cell currents return nearly to 0 nA. C: voltage dependence of activation (red-filled square) and inactivation (blue-filled circle) (unpublished data). D: topology of Nav1.5 in the plasma membrane with accessory proteins implicated in LQTS.