Table 5.
Phenotypic similarities between arrhythmogenic properties in murine Scn5a+/− and Scn5a+/Δkpq hearts and human BrS and LQTS3
| Model | Phenotype | Mouse | Human | Reference Nos. |
|---|---|---|---|---|
| Scn5a+/− compared with BrS | Arrhythmic phenotype unmasked by flecainide | + | + | 150, 344, 914, 1270 |
| Arrhythmic phenotype relieved by quinidine | + | + | 92, 421, 792 | |
| Positive ΔAPD90 persistent with flecainide and quinidine | + | − | 743, 1095 | |
| RVOT/right ventricular initiation of arrhythmia | + | + | 734–736, 741, 754, 1336 | |
| Fibrotic change with age | + | + | 500–503 | |
| Presence of male/female phenotypic differences | + | + | 500–503 | |
| Scn5a+/Δkpq compared with LQTS3 | Arrhythmic phenotype reduced by flecainide | + | + | 94, 914, 1096, 1263 |
| Arrhythmic phenotype exacerbated by quinidine | + | + | 207 | |
| Negative ΔAPD90 rescued by flecainide | + | + | 94, 1096 | |
| Absence of male/female phenotypic differences | + | + | 684, 1096, 1321 |