Table 7.
Transgenic murine models for catecholaminergic polymorphic ventricular tachycardia (CPVT)
| Gene | Genetic Modification | Phenotype | Reference Nos. |
|---|---|---|---|
| RyR2 (NH2-terminal region) | RyR2-R176Q/+ | CPVT (ARVC2) | 534 |
| RyR2-R420W | CPVT | 851 | |
| RyR2 (central region) | RyR2-P2328S/+ and RyR2-P2328S/P2328S | CPVT | 364, 1340 |
| RyR2-P2328S/P2328S | AF | 569, 832, 996, 1334, 1337 | |
| RyR2-R2474S/+ | CPVT | 585, 629, 1156 | |
| RyR2 (COOH-terminal region) | RyR2-R4496C/+ | CPVT | 172, 673 |
| Casq2 | Casq2-D307H overexpression | CPVT | 266 |
| Casq2−/− | CPVT and cardiac hypertrophy | 581 | |
| Casq2+/− | No phenotype | 199 | |
| Casq2-D307H/D307H | Spontaneous arrhythmias | 1078 | |
| Casq2-ΔE9/ΔE9 | Spontaneous arrhythmias; cardiac hypertrophy with age | 1077 | |
| Casq2-R33Q/R33Q | Spontaneous arrhythmias | 951 |