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. 2017 Aug 2;11:16. doi: 10.3389/fnint.2017.00016

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Copyright © 2017 Morellini, Malyshev, Volgushev, Chistiakova, Papashvili, Fellini, Kleene, Schachner and Dityatev.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Restoration of CA1 long-term potentiation (LTP) in tenascin-C (TNC^−/−) mice by the L-type voltage-gated Ca²⁺ channel (L-VGCC) activator Bay K-8644. (A) Four trains of theta-burst stimulation (TBS) of Schaffer collateral/commissural fibers induced impaired LTP in the CA1 region of TNC^−/− mice. (B) LTP in TNC^−/− mice can be restored to wild-type levels by the L-VGCC activator Bay K-8644 (10 μM). Mean and SEM values are shown, the mean slope of field excitatory postsynaptic potentials (fEPSPs) recorded 10 min before the induction of LTP was set to 100%.