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The long lasting firing rate effects from Bindman et al. (1964). The top trace shows the activity recorded from S1 of an anesthetized rat elicited by forepaw stimulation. The effects of about 8 minutes of low amplitude stimulation doubles the firing rate for 45 minutes, another 8 minutes doubles the activity again. The bottom panel shows how cathodal stimulation shows the opposite effects with about 8 minutes of stimulation requiring hours before the firing rates normalize.
