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. 2017 Aug 2;8:912. doi: 10.3389/fimmu.2017.00912

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Copyright © 2017 Hollander and Haimovich.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A schematic model of B-cell antigen receptor (BCR) engagement in follicular lymphoma (FL). (A) FL in which high-mannose glycan in the immunoglobulin (Ig) variable region prevents binding of cognate autoantigen to the BCR. The glycan interacts with DC-SIGN expressed by dendritic cells and macrophages, hence triggers FL cell activation. (B) FL in which the BCR is capable of antigen recognition and signaling despite the presence of a glycan in its active site. It is not clear whether concurrent interaction of the high-mannose glycan with DC-DIGN takes place.