Table 3. Summary of results of the meta-analysis from different comparative genetic models.
| Comparison | OR (95% CI) | P-value | P for heterogeneity | I2 (%) | Model |
|---|---|---|---|---|---|
| T versus C | |||||
| Total | 1.05 (0.93, 1.19) | 0.421 | 0.002 | 70.8 | Random |
| Ethnicity | |||||
| Mixed | 1.03 (0.88, 1.21) | 0.695 | 0.001 | 79.8 | Random |
| Asians | 1.15 (0.91, 1.45) | 0.255 | |||
| Caucasians | 1.08 (0.87, 1.34) | 0.489 | |||
| Cancer type | |||||
| CRC | 1.04 (0.85, 1.28) | 0.718 | 0.001 | 79.3 | Random |
| CC | 1.08 (0.97, 1.19) | 0.158 | |||
| RC | 1.09 (0.94, 1.27) | 0.240 | |||
| Genotype method | |||||
| TaqMan | 1.04 (0.85, 1.28) | 0.718 | 0.001 | 79.3 | Random |
| Golden Gate assay | 1.08 (0.99, 1.18) | 0.064 | 0.875 | <0.001 | Random |
| TT versus CC | |||||
| Total | 1.14 (0.91, 1.43) | 0.257 | 0.029 | 57.3 | Random |
| Ethnicity | |||||
| Mixed | 1.13 (0.84, 1.52) | 0.435 | 0.008 | 71.1 | Random |
| Asians | 1.26 (0.78, 2.04) | 0.346 | |||
| Caucasians | 1.07 (0.64, 1.78) | 0.793 | |||
| Cancer type | |||||
| CRC | 1.08 (0.76, 1.54) | 0.674 | 0.014 | 67.8 | Random |
| CC | 1.31 (1.03, 1.66) | 0.029 | |||
| RC | 1.18 (0.84, 1.65) | 0.330 | |||
| Genotype method | |||||
| TaqMan | 1.08 (0.76, 1.54) | 0.674 | 0.014 | 67.8 | Random |
| Golden Gate assay | 1.26 (1.04, 1.54) | 0.019 | 0.630 | <0.001 | Random |
| TT + CT versus CC | |||||
| Total | 1.03 (0.87, 1.20) | 0.758 | 0.009 | 64.7 | Random |
| Ethnicity | |||||
| Mixed | 1.00 (0.82, 1.22) | 0.999 | 0.003 | 74.9 | Random |
| Asians | 1.09 (0.71, 1.67) | 0.694 | |||
| Caucasians | 1.16 (0.86, 1.55) | 0.336 | |||
| Cancer type | |||||
| CRC | 1.01 (0.77, 1.32) | 0.929 | 0.005 | 72.8 | Random |
| CC | 1.03 (0.90, 1.18) | 0.632 | |||
| RC | 1.12 (0.92, 1.37) | 0.253 | |||
| Genotype method | |||||
| TaqMan | 1.01 (0.77, 1.32) | 0.929 | 0.005 | 72.8 | Random |
| Golden Gate assay | 1.06 (0.95, 1.19) | 0.299 | 0.499 | <0.001 | Random |
| TT versus CT + CC | |||||
| Total | 1.16 (0.98, 1.37) | 0.078 | 0.140 | 37.8 | Random |
| Ethnicity | |||||
| Mixed | 1.15 (0.93, 1.43) | 0.205 | 0.063 | 55.1 | Random |
| Asians | 1.27 (0.90, 1.81) | 0.175 | |||
| Caucasians | 0.98 (0.61, 1.59) | 0.949 | |||
| Cancer type | |||||
| CRC | 1.10 (0.86, 1.42) | 0.78 | 0.076 | 52.7 | Random |
| CC | 1.32 (1.05, 1.66) | 2.36 | |||
| RC | 1.12 (0.81, 1.54) | 0.70 | |||
| Genotype method | |||||
| TaqMan | 1.10 (0.86, 1.42) | 0.78 | 0.076 | 52.7 | Random |
| Golden Gate assay | 1.25 (1.03, 1.50) | 2.32 | 0.415 | <0.001 | Random |
| TC versus CC | |||||
| Total | 0.99 (0.86, 1.14) | 0.866 | 0.056 | 51.1 | Random |
| Ethnicity | |||||
| Mixed | 0.96 (0.81, 1.15) | 0.668 | 0.030 | 62.7 | Random |
| Asians | 0.99 (0.63, 1.55) | 0.951 | |||
| Caucasians | 1.17 (0.86, 1.60) | 0.304 | |||
| Cancer type | |||||
| CRC | 0.97 (0.77, 1.22) | 0.789 | 0.040 | 60.2 | Random |
| CC | 0.98 (0.85, 1.13) | 0.809 | |||
| RC | 1.11 (0.90, 1.37) | 0.329 | |||
| Genotype method | |||||
| TaqMan | 0.97 (0.77, 1.22) | 0.789 | 0.040 | 60.2 | Random |
| Golden Gate assay | 1.02 (0.91, 1.15) | 0.727 | 0.056 | 51.1 | Random |